Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the risk of AD. Relevant studies were identified from PubMed, EMBASE, and China National Knowledge Infrastructure up to October 2012. Data were available from a total of 7 case-control studies with 2504 cases and 2322 controls. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to investigate the strength of the association. The results showed no significant association between PIN1-842G/C polymorphism and AD risk in all comparison models (GG vs. GC: OR=0.84, 95%CI=0.61-1.18; GG vs. CC: OR=0.70, 95%CI=0.35-1.41; GC vs. CC: OR=0.81, 95%CI=0.39-1.69; G vs. C: OR=0.89, 95%CI=0.69-1.17; GG vs. GC+CC: OR=0.81, 95%CI=0.56-1.17; GG+GC vs. CC: OR=0.72, 95%CI=0.36-1.45). For the PIN1-667T/C polymorphism, lack of an association was also found. Subgroup analyses by the ethnicity and patients with late-onset AD did not change the results. Conclusively, the present meta-analysis revealed that PIN1 gene polymorphisms (-842G/C and -667T/C) were unlikely to contribute to AD susceptibility.
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